RECURRENT MISCARRIAGE

Recurrent miscarriage and infertility are a problem, which may result from a primary thrombophilic disorder in as many as 50% of cases. As an adjunct to evaluation by gynecologists and reproductive specialists, testing for thrombophilia has become a key aspect of the diagnostic work-up. Identification for the responsible defect of blood coagulation proteins and/or platelets may lead to specific and highly effective therapy. In come studies adapting this multidisciplinary approach to evaluation and treatment has resulted in a rate of successful pregnancy of over 90%. Women with recurrent miscarriage and infertility for whom no other etiology can be identified are a major focus of the services offered at CALIFORNIA CLINICAL THROMBOSIS CENTER.

• Fetal Wastage Syndrome
• Placental vascular thrombosis
• Defects in blood proteins or platelets underlie 30% to 50% of cases
• Etiologies include:
  • Antiphospholipid antibodies 60%
  • Sticky Platelet Syndrome 30%
  • Antithrombin deficiency 10%
  • Protein C deficiency 10%
  • Protein S deficiency 10%
  • Factor V Leiden deficiency 10%