THROMBOSIS, HEMOSTASIS, AND VASCULAR MEDICINE

Defects of Blood Proteins and Platelets

Thrombosis, hemostasis and vascular medicine is an emerging specialty which represents an integration of clinical and laboratory medicine. Patients with arterial thrombosis include those with coronary artery disease and myocardial infarction, transient ischemic attack, stroke and peripheral arterial thrombosis. Patients with venous thrombosis include those with deep vein thrombosis and pulmonary embolism. Pregnant patients may experience placental thrombosis as the cause of recurrent miscarriage. A number of defects of blood proteins and platelets may result in either thrombosis:(Thrombophilia) or hemorrhage (Hemorrhagic Diathesis).

Thrombophilic Disorders

• Antithrombin defects
• Protein C defects
• Proteins S defects
• Prothrombin G20210A mutation
• Dysfibrinogenemia
• Sticky platelet syndrome
• APC resistance
• Anticardiolipin antibodies
• Lupus anticoagulant
• Heparin cofactor II defects
• Plasminogen defects
• TPA defects
• PAI-1 defect
• Factor XII defects
• vWF elevation
• Hyperhomocyst(e)inemia
• MTHFR mutation

Hemorrhagic Diatheses

• Fibrinogen defects (factor II)(dysfunctional and deficiency state)
• Factor VIII:C defects (inhibitor, deficiency)
• Factor IX defects (dysfunctional and deficiency)
• Factor X defects
• Factor XII defects
• Factor XIII defects
• High Molecular Weight Kininogen defects
• Von Willebrand’s disease
• Thrombocytopenia
• Platelet storage pool disease
• Glanzman’s thrombasthenia
• Bernard Soulier syndrome
• Hereditary Hemorrhagic Telangiectasia
• Disseminated Intravascular Coagulation
• Primary Fibrinolysis
• Thrombotic Thrombocytopenic Purpura
• Henoch Schoenlein Purpura
• Hemolytic Uremic Syndrome